Seesmic

Seesmic is a native client that lets you manage one or more Twitter accounts quickly and easily.

With a look that melds seamlessly with the Windows interface, Seesmic displays in an organized way the timelines for each and every account you have configured.

Apart from multiple account support, Seesmic lets you make lists, publish images, and shorten URLs. It also includes an integrated search feature and syncing for saved searches.

If you use Twitter often and your preferred operating system is Windows, Seesmic is one of the most comprehensive account managers you can find.